A Study of the Conformation of Some β-blockers

Chem. J. Chinese Universities ›› 1995, Vol. 16 ›› Issue (1): 75.

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A Study of the Conformation of Some β-blockers

XU You-Xuan, ZHANG Chang-Jiu, SHEN Li, WU Yun, WAN Shan

China Doping Control Centre, National Research Institute of Sports Medicince, Beijing, 100029

Received:1994-01-18 Revised:1991-04-12 Online:1995-01-24 Published:1995-01-24

Abstract

Abstract: An improved procedurehs been established for the confirmation of some β-blockers in doping control analysis. The derivatives of the drugs and their metabolites have very similar mass spectra and retention time in our previous work, and it's very difficult to distinguish them. The derivatization and the extraction are performed simultaneously by using phosgene as the derivatization reagent in the new procedure. The new derivatives in this paper have very chracteristic mass spectra, and are easy to be confirmed.

Key words: β-Blocker, Phosgene, GC/MS, Derivatization

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XU You-Xuan, ZHANG Chang-Jiu, SHEN Li, WU Yun, WAN Shan. A Study of the Conformation of Some β-blockers[J]. Chem. J. Chinese Universities, 1995, 16(1): 75.

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A Study of the Conformation of Some β-blockers

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