Studies on Fluorescent Ptoperty of Degradation Product of Cephalexin and Its Analytical Application

Chem. J. Chinese Universities ›› 1995, Vol. 16 ›› Issue (1): 26.

• Articles • Previous Articles Next Articles

Studies on Fluorescent Ptoperty of Degradation Product of Cephalexin and Its Analytical Application

HE Xi-Wen, TANG Bo, SHEN Han-Xi

Department of Chemistry, Nanhai University, Tianjin, 300071

Received:1994-03-26 Revised:1994-08-20 Online:1995-01-24 Published:1995-01-24

Abstract

Abstract: In this paper, the degradation reactions of cephalexin in acid and alkali media are deseribed in detail,and the corresponding fluorometric methods of cephalexin are presented by producing its stable fluorescent products. The linear ranges are 0. 50-100 ng/mL (acid degradation) and 2.0─70 ng/mL (alkali degradation), respectively. The fluorometry with acid degradation has more advantages of analytical precission and is more accuracy than that with alkali degradation,which has been used for the determination of trace cephalexin in human serum and urine with satisfactory results.

Key words: Cephalexin, Degradation reaction, Fluorometry

TrendMD:

HE Xi-Wen, TANG Bo, SHEN Han-Xi. Studies on Fluorescent Ptoperty of Degradation Product of Cephalexin and Its Analytical Application[J]. Chem. J. Chinese Universities, 1995, 16(1): 26.

[1]	MA Jian, ZHANG Zhi-Qi* . Flow Injection On-line Oxidizing Fluorometry Coupled to Dialysis Sampling for Studying Thioridazine Hydrochloride-Bovine Serum Albumin Binding [J]. Chem. J. Chinese Universities, 2007, 28(7): 1255.
[2]	FENG Feng, WANG Ke-Min, CHEN Qi-Ting, XIANG Qiu-Fen, CHEN Ze-Zhong, HUANG Hong-Mei, HUANG Shan-Sheng, HUO Xi-Qin. Application of Capillary Enzyme Column Enhancd by Using Nanoparticles for Glucose Biosensor Based on Liquid Droplets [J]. Chem. J. Chinese Universities, 2004, 25(7): 1257.
[3]	MAO Yu-Xia, ZHENG Hong, GUO Xiang-Qun, CHEN Rong, ZHENG Wei-Yun . Studies on the Fluorometric Method for Determining Activity of Catalase and Its Application to Marine Biosamples [J]. Chem. J. Chinese Universities, 2002, 23(10): 1864.
[4]	CHENG Yi, LIN Hua-Kuan, WANG Kui. Studies on Kinetics of Reaction Between Tb ³⁺ and Human Oxyhemoglobin by Stopped-flow Fluorometry [J]. Chem. J. Chinese Universities, 1998, 19(6): 876.
[5]	LI Qing-Ge, XU Jin-Gou, HUANG Xian-Zhi, CHEN Guo-Zhen . Non-enzymatic System for Catalytic Fluorometric Determination of Glucose Oxidase [J]. Chem. J. Chinese Universities, 1997, 18(1): 52.
[6]	LIU Shu-Ping, HUANG Han-Guo. Simultaneous Determination of Europium and Terbium by Derivative Fluorometry with Pyrazine-2,3-Dicarboxylic acid System [J]. Chem. J. Chinese Universities, 1995, 16(4): 523.
[7]	CI Yun-Xiang, CHEN Yong, LI Yuan-Zong, CNANG Wen-Bao. The Application of DTPA-Eu³⁺Complex to DNA Hybridization Assay [J]. Chem. J. Chinese Universities, 1995, 16(2): 184.
[8]	LI Jia, PAN Zu-Ting, XU Mian-Yi . Studies on the Mechanism of Coordination Reaction of Porphyrins with Some Metal Ions by Fluorometry [J]. Chem. J. Chinese Universities, 1992, 13(11): 1368.
[9]	Wen Zhiming, Wang Huaigong . The Study on the Spectrofluorometric Determination of Microamounts of Palladium(Ⅱ) with Food Colour Tartrazine [J]. Chem. J. Chinese Universities, 1989, 10(5): 462.
[10]	Zhang Luduan, Liu lianqing, Zhang Zhujun . Determination of Trace Copper in Natural Water by Fluororoetry [J]. Chem. J. Chinese Universities, 1988, 9(5): 516.

Studies on Fluorescent Ptoperty of Degradation Product of Cephalexin and Its Analytical Application

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 10

Recommended Articles

Metrics

Comments