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Chem. J. Chinese Universities

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Quantum Chemistry Calculation on 5'-pTpTpCp-3' Cleavage by Serine/Histamine Amide

LIU Hua-Nai1*, WANG Bing-Feng2, SUN Ming3, ZHANG Lei1   

    1. School of Chemical Enqineering and Energy Engineering, South China University of Technology, Guangzhou 510640,China;
    2. College of Science, South China Agriculture University, Guangzhou 510642, China;
    3. Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
  • Received:2006-06-07 Revised:1900-01-01 Online:2007-08-10 Published:2007-08-10
  • Contact: LIU Hua-Nai

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Abstract: A quantum chemistry calculation was carried out to study the mechanism of 5'-pTpTpCp-3' cleavage by the L/D-Ser-Hism. The effective molecular recognition between L/D-Ser-Hism and DNA through multi-hydrogen-bonds and the corresponding structural parameters were obtained. The results could be used to explain the mechanism of DNA cleavage by L/D-Ser-Hism.

Key words: L/D-Ser-Hism, 5’-pTpTpCp-3’segment, Cleavage mechanism

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