Chem. J. Chinese Universities

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Self-assembly of Amphiphilic Linear-hyperbranched Multi-arm Copolymer into Cationic Vesicles

TIAN Hua-Yu, XIA Jia-Liang, LIN Hao, CHEN Lei, CHEN Xue-Si, LI Yue-Sheng, JING Xia-Bin   

  1. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  • Received:2005-12-13 Revised:1900-01-01 Online:2006-09-10 Published:2006-09-10
  • Contact: CHEN Xue-Si

Abstract:

Amphiphilic linear-hyperbranched multi-arm copolymer poly(ethylene glycol)-polyethylenimine-poly(γ-benzyl L-glutamate)(PEG-PEI-PBLG) can self-assemble into cationic vesicles in aqueous solution. TEM, DLS, SLS and zeta potential measurement were used to characterize the structure of the PEG-PEI-PBLG vesicles. The vesicles were constituted of 5—10 nm bimolecular layers with average diameter in 100 nm and surface zeta potential of +25.2 mV. The positive charges on vesicles surface were caused by the protonation of PEI in aqueous solution. The cationic vesicles have an ability to carry negatively charged proteins.

Key words: Hyperbranched multi-arm copolymer, Self-assembling, Vesicles, Polyethylenimine

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