Chem. J. Chinese Universities ›› 2000, Vol. 21 ›› Issue (5): 729.

• Articles • Previous Articles     Next Articles

Synthetic Studies of HIV-active Didemnaketal A Analogue ──Synthesis of a C1-C7 Fragment

JIA Yan-Xing, WANG Ping-Zhen, WU Bin, TU Yong-Qiang   

  1. Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China
  • Received:1999-05-25 Online:2000-05-24 Published:2000-05-24

Abstract: AC1-C7 fragment of the HIV-active Didemnaketal Aanalogue was synthesized from (R)-pulegone through 12 steps. Two new chiral centers, C3, C4 were successfully constructed by the steric induction in this approach and the aldehyde was selectively reduced.

Key words: Spiroketal, Intermediated Chiral synthesis

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