Synthesis of Unsaturated Polyphosphoesteran Injectable Bone Tissue Engineering Scaffold Material

Chem. J. Chinese Universities ›› 2005, Vol. 26 ›› Issue (10): 1952.

• Articles • Previous Articles Next Articles

Synthesis of Unsaturated Polyphosphoesteran Injectable Bone Tissue Engineering Scaffold Material

QIU Jin-Jun^1,2, LIU Cheng-Mei¹, HU Fen¹, GUO Xiao-Dong³, ZHENG Qi-Xin^2,3

1. Department of Chemistry,Huazhong University of Science and Technology;
2. College of Life Science and Technology,Huazhong University of Science and Technology;
3. Xiehe Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430074,China

Received:2004-10-12 Online:2005-10-10 Published:2005-10-10

Abstract

Abstract: Unsaturated polyphosphoester(UPPE) containing unsaturated olefinic bonds in repeat units was synthesized by fumaric acid,1,2-propylene glycol and phosphorous oxytrichloride as the initiation materials.Three kinds of isomers of bis(1,2-propyleneglycol) fumarate were detected in main chain of UPPE by FTIR and NMR.The effect of reaction time on condensation polymerization reaction was investigated with GPC.High and uniform molecular weight of polymer can be obtained by extending polymerization reaction time.The molecular weight is 5 956 g/mol and the polymer dispersion degree is 1.12 after refluxing for 18 h.The temperature curve of UPPE crosslinked with N-vinyl pyrrolidone indicated that the maximum temperature is from 41.14 to 82.30 ℃,and the setting time is between 1.95 min and 10.28 min.

Key words: Unsaturated polyphosphoester, Bis(1,2-propyleneglycol) fumarate, Biomacromolecules, Bone tissue engineering soaffold material

CLC Number:

O631

TrendMD:

QIU Jin-Jun, LIU Cheng-Mei, HU Fen, GUO Xiao-Dong, ZHENG Qi-Xin. Synthesis of Unsaturated Polyphosphoesteran Injectable Bone Tissue Engineering Scaffold Material[J]. Chem. J. Chinese Universities, 2005, 26(10): 1952.

References

[1] Zhao Z.,W ang J.,M aoH.Q.etal..A dvan ced D rug D elivery R eview s[J],2003,55:483-499 [2] W ang S.,W an A nd rew C.A.,X u X.Y.etal..B iomaterials[J],2001,22:1157-1169 [3] W ang J.,M ao H.Q.,Leong.K am W..Journ al of Am erican Chem ist ry Society[J],2001,123:9480-9481 [4] D ah iyat B..I,R ichards M.,Leong.K.W..Jou rnal of Con trolled R elease[J],1995,33:13-21 [5] Tem eno J.S.,M icos A.G..B iom aterials[J],2000,21:2405-2412 [6] FU Jie(傅杰),ZHUO R en-X i(卓仁禧),FAN Ch ang-L ie(范昌烈).Ch em.J.Ch in ese U n ivers it ies(高等学校化学学报)[J],1997,18(5):813-817 [7] K E T ian Y i(柯天一),ZHUO R en-X i(卓仁禧).A cta Polym erica S in ica(高分子学报)[J],1997,(5):573577 [8] D ah iyat B.J.,Posadas E.M.,H irosue S.etal..R eact ive Polym er[J],1995,25:101-109 [9] LU O Y i(罗毅),ZHUO R en-X i(卓仁禧),FAN Chang-L ie(范昌烈).C hem.J.Ch in ese U n iversit ies(高等学校化学学报)[J],1995,16(10):1633-1636 [10] LUO Y i(罗毅),ZHUO R en-X i(卓仁禧),FAN Ch ang-L ie(范昌烈).Ch inese Jou rnal of Pharm aceu ticals(中国医药工业杂志)[J],1996,27(1):6-7 [11] W ang J.,Zhuo R.X..European Polym er Journ al[J],1999,35:491-497 [12] CAO Y ou(曹悠),LIU Cheng-M ei(刘承美),HU H ao(胡灏)etal..Jou rnal of Hu azhong U n ivers ity of Scien ce and Techno logy,N ature S cien ce(华中科技大学学报,自然科学版)[J],2003,31(2):114-116 [13] Jam es C.W ygan,tC reve C oeu ,rE rhard J.Prill etal.U S Patent 3360546[P],1967 [14] Saunders B.C.,Stacey G.J.,W ild F.e t a .l.Journal of Ch em istry Society[J],1948,1:699-703 [15] Pascual B.,V azqu ez B.,G urruchuagaM.e t a .l.B iomaterials[J],1996,17:509-516 [16] M ahesh V.Chauba,l W ang B.,Su G.D.etal.Journal of A pp lied Po lym er S cien ce[J],2003,90:4021-4031 [17] Jefferiss C.D.,L ee A.J.C.,L ing R.S.M..Jou rnal of Bon e Jo int Surgery[J],1975,57B:511-518

Synthesis of Unsaturated Polyphosphoesteran Injectable Bone Tissue Engineering Scaffold Material

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 1

Recommended Articles

Metrics

Comments