CJCU

Chem. J. Chinese Universities

• 研究论文 • Previous Articles     Next Articles

New Diterpenoid Compound from Rabdosia macrocalyx

SHI Hao1, HE Shan1, HE Lan2, PAN Yuan-Jiang1   

    1. Department of Chemistry, Zhejiang University, Hangzhou 310027, China;
    2. Department of Chemistry, Beijing Normal University, Beijing 100085, China
  • Received:2006-01-15 Revised:1900-01-01 Online:2007-01-10 Published:2007-01-10
  • Contact: PAN Yuan-Jiang

PDF (PC)

Abstract:

On the basis of the investigation on natural product antitumor agents, a new diterpenoid named macrocalyxin J was isolated from the leaves of Rabdosia macrocalyx(Dunn) Hara by silica gel column chromatography. Based on IR, MS, 1H NMR, 13C NMR and 2D NMR spectroscopies, the structure of macrocalyxin J was determined as (1α,6β,11β,14α)-1,7∶6,20-diepoxy-6,11-dihydroxy-6,7-seco-ent-kaur-16-ene-7,15-dione-14-acetate. The antitumor activity of the compound was assayed by MTT method. Macrocalyxin J was shown to have a potency in vitro against the cultures of Hela cells.

Key words: Rabdosia macrocalyx, B-seco-ent-kaurene, Macrocalyxin J

CLC Number: 

TrendMD: