Inhibition Mechanism of α-Glucosidase by Dawson-Type Polyoxometalate-Vitamin C Complexes

doi:10.7503/cjcu20250236

Chem. J. Chinese Universities

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Inhibition Mechanism of α-Glucosidase by Dawson-Type Polyoxometalate-Vitamin C Complexes

HUANG Xinyi, QUE Maomei, LI Yao, LEI Shan, LIN Siqi, WANG Li

College of Marine Food and Biological Engineering, Jimei University

Received:2025-08-28 Revised:2025-11-23 Online First:2025-11-26 Published:2025-11-26
Supported by:
Supported by the National Natural Science Foundation of China (No.22271119)

Abstract

Abstract: This study investigated the inhibitory effects of Dawson-type polyoxometalates (POMs) complexed with vitamin C (VC) on α-glucosidase activity. Four Dawson-type phosphomolybdates were synthesized and characterized, including the parent compound H?[P?Mo??O??] (P?Mo??) and three transition metal-substituted derivatives (H?[P?Mo??Fe(OH?)O??] (P?Mo??Fe), H?[P?Mo??Co(OH?)O??] (P?Mo??Co), and H?[P?Mo??Ni(OH?)O??] (P?Mo??Ni)). Enzyme kinetic studies revealed that all four POM-VC complexes exhibited significant inhibitory activity against α-glucosidase. The optimal inhibition ratios were determined to be 5:1 for P?Mo??-VC, 3:1 for P?Mo??Fe-VC and P?Mo??Ni-VC, and 2:1 for P?Mo??Co-VC, with corresponding IC?? values of 0.194 mM, 2.507 mM, 2.809 mM, and 5.332 mM, respectively. Mechanistic studies demonstrated that these complexes functioned as reversible mixed-type inhibitors. These findings suggest the potential of Dawson-type POM-VC complexes as novel α-glucosidase inhibitors for diabetes management.

Key words: Polyoxometalates, α-Glucosidase, Vitamin C, Enzyme inhibition, Kinetic

CLC Number:

TS201.2
O6

TrendMD:

HUANG Xinyi, QUE Maomei, LI Yao, LEI Shan, LIN Siqi, WANG Li. Inhibition Mechanism of α-Glucosidase by Dawson-Type Polyoxometalate-Vitamin C Complexes[J]. Chem. J. Chinese Universities, doi: 10.7503/cjcu20250236.

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Inhibition Mechanism of α-Glucosidase by Dawson-Type Polyoxometalate-Vitamin C Complexes

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