Preparation and Controlled Release of Multifunctional Avermectin Nano-pesticide†

doi:10.7503/cjcu20180702

Abstract

Abstract:

Based on the two active hydroxyl groups, avermectin reacted with acryloyl chloride, tetraethylenepentamine and succinic anhydride consecutively to obtain a new kind of emulsifier precursor with ester bonds and drug affinity. The structure of the emulsifier precursor was characterized by various techniques. After neutralization, the emulsifier and avermectin could form a stable nanoemulsion in water spontaneously. The particle size of the nanoemulsion could be adjusted by drug loading and neutralization extent. The nanoemulsion exhibited a series of good properties, including high drug loading, high stability, photolysis resistance, low surface tension and high leaf affinity. The ester bonds in the emulsifier could be hydrolyzed in presence of esterase or under strong alkaline, so that the hydrophilic part of the emulsifier could be separated from the lipophilic part, promoting the releasing of avermectin from the particles. Therefore, this nano pesticide exhibited a better insecticidal effect than the commercial avermectin emulsifiable concentrate(EC).

Key words: Avermectin, Nano pesticide, Controlled releasing, Ester bond

CLC Number:

O633.2

TrendMD:

GUAN Wenxun,TANG Liming. Preparation and Controlled Release of Multifunctional Avermectin Nano-pesticide^†[J]. Chem. J. Chinese Universities, 2019, 40(5): 1096.

Figures/Tables 10

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Sample	C(%)	H(%)	O(%)	N(%)
Pure avermectin	65.9	8.3	25.7	0
Actual value of acrylated avermectin	65.5	7.6	27.1	0.1
Calculated value of acrylated avermectin	66.1	7.7	26.4	0
Actual value of emulsifier	58.2	7.4	29.0	5.1
Calculated value of mono-addition emulsifier	59.7	7.3	28.5	4.5
Calculated value of bis-addition emulsifier	56.7	7.1	29.6	6.5

Sample	C(%)	H(%)	O(%)	N(%)
Pure avermectin	65.9	8.3	25.7	0
Actual value of acrylated avermectin	65.5	7.6	27.1	0.1
Calculated value of acrylated avermectin	66.1	7.7	26.4	0
Actual value of emulsifier	58.2	7.4	29.0	5.1
Calculated value of mono-addition emulsifier	59.7	7.3	28.5	4.5
Calculated value of bis-addition emulsifier	56.7	7.1	29.6	6.5

Sample No.	Drug loading(%)	Molar ratio of emulsifier to triethanolamine	Particle diameter/nm	Polymer dispersity index(PDI)
1	33	1∶12	69	0.20
2	50	1∶8	176	0.38
3	50	1∶10	105	0.32
4	50	1∶12	96	0.28
5	57	1∶12	196	0.65

Sample No.	Drug loading(%)	Molar ratio of emulsifier to triethanolamine	Particle diameter/nm	Polymer dispersity index(PDI)
1	33	1∶12	69	0.20
2	50	1∶8	176	0.38
3	50	1∶10	105	0.32
4	50	1∶12	96	0.28
5	57	1∶12	196	0.65

Sample	Retention/(mg·cm^-2)
Sample	On rice	On cucumber	On cabbage
Avermectin nanoemulsion	17.3±1.1	21.9±1.5	34.1±2.5
Deionized water	2.2±0.3	9.9±0.5	21.3±0.8
Avermectin EC	8.7±0.6	13.7±0.8	22.7±1.3