Synthesis and Biological Evaluation of VPI-7 Zeolite†

doi:10.7503/cjcu20170330

Abstract

Abstract:

Porous zincosilicate zeolite, VPI-7, was synthesized through hydrothermal approach, and the size of samples were adjusted by varying amounts of sol. Also, the biological properties of the samples were charactered. The characteristic results showed that the prepared samples were aggregated into microspheres by VPI-7 rod-shaped crystals, and the crystals further cross-linked and formed numerous micron-sized pores, which provided good morphological features for their biological properties. In addition, the surface topography for VPI-7 had the ability to promote the deposition of calcium phosphate, and load/release protein. The in vitro experiments suggested that VPI-7 was conducive to cell adhesion and proliferation, with good biocompatibility. VPI-7 showed excellent biological properties, and has potential to be applied as implant used in bone repair and replacement.

Key words: Zincosilicate zeolite VPI-7, Biocompatibility, Load/release protein

CLC Number:

O614
R318

TrendMD:

LI Ruiyan, WANG Shuang, LI Dongdong, QIN Yanguo, YU Jihong. Synthesis and Biological Evaluation of VPI-7 Zeolite^†[J]. Chem. J. Chinese Universities, 2017, 38(11): 1935.

Figures/Tables 6

Fig.1 Photograph of the VPI-7 discs with different sizes(A), XRD powder patterns of VPI-7(B) and SEM images of VPI-7 at different magnifications(C, D) (B) a. Experimental; b. simulated.

Fig.2 SEM images of r-BMSCs cultured on VPI-7 sample for 2 d (A) 250×; (B) 1000×. Red arrow: filopodia.

Fig.3 Cytotoxicity test of VPI-7 * P<0.05; NS: not significant.

Fig.4 Cell proliferation of different groups* Indicates statistical significance P<0.05 vs. VPI-7.# Indicates statistical significance P<0.05 vs. TCPS.

Fig.5 Release of protein from VPI-7

Fig.6 SEM images with different magnifications(A, B) and EDS pattern(C) of VPI-7 after immersed in SBF for 72 h and

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