Design and Synthesis of Photolabeling Probes for the Study of Antiviral Mechanism of Ribavirin

Chem. J. Chinese Universities

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Design and Synthesis of Photolabeling Probes for the Study of Antiviral Mechanism of Ribavirin

ZHU Xun^1,2*, QU Fan-Qi³

1. The State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China;
2. School of Material Science and Engineering, Wuhan Institute of Chemical Technology, Wuhan 430074, China;
3. College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, China

Received:1900-01-01 Revised:1900-01-01 Online:2006-06-10 Published:2006-06-10
Contact: ZHU Xun

Abstract

Abstract: The photolabeling probes for the study of antiviral mechanism of ribavirin were designed, and the synthesis experiments were carried out by using 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose and methyl 3-bromo-1,2,4-triazole-5-carboxylate as the raw materials. Two photolabeling probes for the study of antiviral mechanism of ribavirin, 5-azido-1-(β-ribofuranosyl)-1,2,4-triazole-3-carboxamide and 3-azido-1-(β-ribofuranosyl)-1,2,4-triazole-5-carboxamide were synthesized, and characterized by IR, MS and 1H NMR, etc.. The design of the photolabeling probes and their structures were discussed.

Key words: Ribavirin, Photolabeling probe, Aizdotriazoles, Design, Synthesis

CLC Number:

O627.27

TrendMD:

ZHU Xun^1,2*, QU Fan-Qi³. Design and Synthesis of Photolabeling Probes for the Study of Antiviral Mechanism of Ribavirin[J]. Chem. J. Chinese Universities, doi: .

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Design and Synthesis of Photolabeling Probes for the Study of Antiviral Mechanism of Ribavirin

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