Abstract:

Some analytical methods, such as titration^[1], TLC^[2], GLC^[3], HPLC^[4] and spectrophotometry^[5] for determination of single ingredient of pseudoephedrine hydrochloride (PSED), paracetamol (PRCT) and dextromethorphan hydrochloride (DEMP) in some mixture have been reported. However, there were no papers for determination of PSED, PRCT and DEMP simultaneously in one tablet. The methods mentioned above needed complex procedures or required some solvents, which might result from pollution, and both of them consumed long time to complete the separation. Therefore it is necessary to develop a new analytical method which could save time and cost.