Preparation and Cell-labeling Function of Monodisperse Core/Shell Structured Quantum Dots/SiO2 with Amino Groups

Chem. J. Chinese Universities

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Preparation and Cell-labeling Function of Monodisperse Core/Shell Structured Quantum Dots/SiO₂ with Amino Groups

ZHANG Bing-Bo¹, GONG Xiao-Qun¹, LIN Ting-Ting², HE Yan-Jin², CHENG Jing¹, SHAN Shun-Yang¹, CHANG Jin^1*

1. Institute of Nanobiotechnology, School of Materials Science & Engineering, Tianjin University, Tianjin 300072, China;
2. Eye Center, Tianjin Medical University, Tianjin 300070, China

Received:2008-06-03 Revised:1900-01-01 Online:2009-02-10 Published:2009-02-10
Contact: CHANG Jin

Abstract

Abstract: Water-soluble silica-coated quantum dots(QDs) were prepared by encapsulating hydrophobic QDs into silica via the reverse microemulsion method. The silica-coated QDs nanoparticles were further modified with 3-aminopropyltriethoxysilane(APTES). The as-prepared samples were characterized with transmission electron microscopy(TEM), particle size analyzer and zeta potential, UV-Vis absorption/Photoluminescence(PL) and Fourier transform infrared spectroscopy(FTIR) measurements. The results show that the silica-coated QDs are well defined with ca. 45 nm, monodisperse, water-soluble, highly-stable. And the as-obtained silica-coated QDs with amino groups can label the cancer cell via the electrostatic attraction.

Key words: Quantum dots, Amino group, SiO₂, Cell-labeling

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ZHANG Bing-Bo¹, GONG Xiao-Qun¹, LIN Ting-Ting², HE Yan-Jin², CHENG Jing¹, SHAN Shun-Yang¹, CHANG Jin^1*. Preparation and Cell-labeling Function of Monodisperse Core/Shell Structured Quantum Dots/SiO₂ with Amino Groups[J]. Chem. J. Chinese Universities, doi: .

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Preparation and Cell-labeling Function of Monodisperse Core/Shell Structured Quantum Dots/SiO₂ with Amino Groups

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