Chem. J. Chinese Universities ›› 1998, Vol. 19 ›› Issue (S1): 232.
• Organic Synthesis Chemistry • Previous Articles Next Articles
Hegui Gong, Zhaolong Li, Hua Fu, Yufen Zhao
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Abstract: It was discovered that polypeptides were formed by self-assembly of N,O-bis(trimethylsilyl)amino acids with the assistance of O-phenylene phosphorochloridate.[1] There were three steps involved in the self organization reactions, the activation of amino acid, the elongation of peptide chain and the termination of the chain reaction,among which the activation of amino acid -the formation of imino (alkyl)acetoxyphosphoranes was the key step. The formation process of the penta-coordinated phosphorus intermediates was showed in scheme 1.[2,3,4] Through further studies of the mechanism of self-assembly reaction, it was found that carbonyl groups of the intermediates attacked by the neuclophilic groups were direct reson of the formation of peptides. However, the peptides in the solution were very difficult to be separated and analyzed.
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Hegui Gong, Zhaolong Li, Hua Fu, Yufen Zhao. A New Method for the Synthesis of Oligo-peptides[J]. Chem. J. Chinese Universities, 1998, 19(S1): 232.
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http://www.cjcu.jlu.edu.cn/EN/Y1998/V19/IS1/232