Chem. J. Chinese Universities ›› 1998, Vol. 19 ›› Issue (S1): 351.
• Organometallic Chemistry • Previous Articles Next Articles
Li Zaiguo, Huang Runqiu, Li Huiying, Liu Xin
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Abstract: α-Aminoalkylphosphonic acids have attracted much attention due to their wide range of biological activities. They serve for inhibiting enzyme activity, bacterial growth and in agrochemistry as antifungal agents, herbicides and plant regulators[1]. In a recent report, α-aminoalkylphosphonates showed very good inhibitory effects against plant virus[2]. At the same time, some derivatives of quinazoline-2,4(1H,3H)-dione also exhibit antiphytoviral activity[3,4]. Considering the wide applications of such compounds, we designed to synthesize some novel quinazoline-2,4(1H,3H)-diones with α-amino-alkylphosphonates moiety, e.g. 3-(α-phenyl-phosphonomethyl)quinazoline-2,4(1H,3H)-dione 4 (scheme Ⅰ).
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Li Zaiguo, Huang Runqiu, Li Huiying, Liu Xin. Synthesis of 3-(α-Phenyl-phosphonomethyl)-quinazoline-2,4(1H,3H)-diones[J]. Chem. J. Chinese Universities, 1998, 19(S1): 351.
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http://www.cjcu.jlu.edu.cn/EN/Y1998/V19/IS1/351