Abstract: A novel temperature-sensitive amphiphilic copolymer of P(NiPAAm-co-DMAA) with active —NH₂ group was synthesized by ATRP, which was used as initiator of amino acid polymerization. The PDI of P(NiPAAm-co-DMAA)-co-P(L-Ala) is about 1.3. This polymer could form temperature-sensitive micelle by self-assembly. The diameter and distribution of micelle were observed by TEM. The results show that the siza of micelle is about 200—300 nm and the micelle has obvious core-shell structure. LCST of copolymer is 45.5 ℃. When temperature is under LCST, the copolymer is soluble and form temperature-sensitive micelle. When temperature is above LCST, the micelle dissociate and copolymer is insoluble. Its response to temperature is quickly and reversible.

Key words: Temperature-sensitive, Self-assembly micelle, P(NiPAAm-co-DMAA)-co-P(L-Ala)