In vitro Studies of Chitosan-based Multifunctional Drug Delivery Nanosystem

doi:10.3969/j.issn.0251-0790.2012.07.039

Abstract

Abstract: The preparation method of a chitosan-based multifunctional nano-drug carrier system and its drug release properties were reported. Methotrexate conjugated chitosan(MTX-CS) was synthesized and characterized, and the substitution degree of MTX was 6.3%. MTX-CS had amphiphilic property, thus could form self-assembled nanoparticles in aqueous medium. The mean diameter of MTX-CS nanoparticles was (269.5±18.3) nm, and the zeta potential was (25.7±0.9) mV. MTX-CS nanoparticles could effectively load antitumor drugcombretastatin A-4(CA-4); CA-4 loading content and entrapment efficiency were 15.7% and 62.8%, respectively, when the feed mass ratio of drug and carrier was 1∶4. The in vitro release experiment shows that CA-4 rapidly releases from MTX-CS nanoparticles, but MTX release rate obviously slows, which is favorable for the combination tumor therapy.

Key words: Chitosan, Multifunctional nanoparticles, Methotrexate, Combretastatin A-4, Combination tumor therapy

CLC Number:

O636
R931

TrendMD:

CHEN Rou, YANG Jin-Rong, YANG Xiao-Ying, WANG Yu-Mei, LI Rong-Shan, WANG Rui-Ling, WANG Yin-Song. In vitro Studies of Chitosan-based Multifunctional Drug Delivery Nanosystem[J]. Chem. J. Chinese Universities, 2012, 33(07): 1586.

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In vitro Studies of Chitosan-based Multifunctional Drug Delivery Nanosystem

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