Preparation of a pH-Responsive Carrier Based on Mesoporous Silica Nanoparticles and Its Application for Controlled Release

doi:10.3969/j.issn.0251-0790.2012.05.009

Chem. J. Chinese Universities ›› 2012, Vol. 33 ›› Issue (05): 914.doi: 10.3969/j.issn.0251-0790.2012.05.009

• Analytical Chemistry • Previous Articles Next Articles

Preparation of a pH-Responsive Carrier Based on Mesoporous Silica Nanoparticles and Its Application for Controlled Release

CAO Jie^1,3,4, HE Ding-Geng^1,3,4, HE Xiao-Xiao^1,2,4, WANG Ke-Min^1,2,3,4, ZHAO Ying-Xiang^1,3,4

1. State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, China;
2. College of Biology, Hunan University, Changsha 410082, China;
3. College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China;
4. Key Laboratory for Bio-Nanotechnology and Molecule Engineering of Hunan Province, Hunan University, Changsha 410082, China

Received:2011-07-16 Online:2012-05-10 Published:2012-05-10

Abstract

Abstract: A pH-responsive carrier was prepared by electrostatic interaction between positively charged mesoporous silica nanoparticles and negatively charged poly(acrylic acid). The physical and chemical properties of the as-synthesized mesoporous silica nanoparticles were characterized by transmission electron microscopy(TEM), X-ray diffraction assay(XRD), Fourier transform infrared spectroscopy(FTIR), Brunauer-Emmett-Teller(BET) and Barrett-Joyner-Halenda(BJH) analyses. Loading efficiency and controlled release properties of the carrier were investigated with Cl₂ dyes as guest molecules. It was demonstrated that the mesoporous silica nanoparticles carrier was very sensitive to pH and exhibited good property of pH-responsive release. At neutral pH, positively charged nanoparticles interacted with negatively charged poly(acrylic acid) by electrostatic adsorption, resulting in the closing of the mesopores. The dyes could hardly be released from the nanoparticles. When the pH value was decreased, the percentage release of dye molecules increased. The dye was released sharply when the pH value was lower than 5. Cumulative release of the dye reached to 98％ at pH=1.0, 280 min. These results demonstrated that the release of the guest molecules could be controlled by pH adjustment. This new type of pH-responsive controlled release system based on mesoporous silica nanoparticles has the advantages of simply synthesis, low cost, and large load capacity, which made it have potential application in drug controlled release.

Key words: Mesoporous silica nanoparticles, Controlled release, Poly(acrylic acid), pH-responsive carrier

CLC Number:

O657

TrendMD:

CAO Jie, HE Ding-Geng, HE Xiao-Xiao, WANG Ke-Min, ZHAO Ying-Xiang. Preparation of a pH-Responsive Carrier Based on Mesoporous Silica Nanoparticles and Its Application for Controlled Release[J]. Chem. J. Chinese Universities, 2012, 33(05): 914.

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Preparation of a pH-Responsive Carrier Based on Mesoporous Silica Nanoparticles and Its Application for Controlled Release

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