Abstract: For the purpose of studying the relation between molecular structure and tuberculostatic activity in acylthiosemicarbazide group, some new derivatives of thiosemicarbazide such as 1-isonicotinoyl-4-halogen-aroyl-thiosemicarbazides have been synthesized.These new compounds ware prepared by developing the reaction of the halogen aroylisothiocyanate with isonicotinoyl hydrazide In acetone, acetonitrile or djoxane in yield of 50-80%.