Chem. J. Chinese Universities ›› 1992, Vol. 13 ›› Issue (7): 947.
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LI Yu-lin, LI Wei-dong, LI Ying
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Abstract: 3,7,11,15-Tetramethyl-12-tert-butyldiphenylsilyl ether-14-oxo-2E,6E,10E-hex-adecatrienal(11), the precursor of isosarcophytol-A, has been synthesized via six steps with (E, E)-farnesol (4) as starting material.The key steps in the synthesis are regionselective oxidation of farnesyl acetate (5) and aldol condensation of aldehyde 8 with methyl isopropyl ketone.
Key words: Macrocyclic diterpenoid, Isosarcophytol-A,3,7,11,15-Tetramethyl-12-tert-butyldiphenylsilyl ether-14-oxo-2E,6E,10E-hexadecatrienal, Aldol condensation
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LI Yu-lin, LI Wei-dong, LI Ying. Studies on Macrocyclic Diterpenoids(Ⅳ)——Synthesis of Isosarcophytol-A Precursor[J]. Chem. J. Chinese Universities, 1992, 13(7): 947.
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http://www.cjcu.jlu.edu.cn/EN/Y1992/V13/I7/947