CJCU

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (2): 210.

• Articles • Previous Articles     Next Articles

Hydrolytic and Electrochemical Property of Antimetastasis NAMI\|A Derivatives Containing Methylimidazole

LIANG Yao-Hua1,2, BI Wei2, YANG Bin2, ZHAO Liang2, LIANG Guo-Gang1,2*   

  1. 1.  Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China;
    2.  Institute of Chinese Material Medica, China Academy of Chinese Medical Science, Beijing 100700,  China
  • Received:2010-08-16 Revised:2010-12-07 Online:2010-02-10 Published:2011-02-23
  • Contact: LIANG Guo-Gang E-mail:lguogang200@126.com
  • Supported by:

    澳门科技发展基金(批准号: 012/2009/A1)、 国家科技部国际合作基金(批准号: 2005DFA30990)和中国中医科学院基本科研业务费自主选题项目(批准号: ZZ2006120, Z02089)资助.

PDF (PC)

Abstract: trans-[RuCl4(DMSO)(4-MeIm)][(4-MeIm)H].HCl (4-MeIm=4-Methylimidazole, Compd.1) and trans-[RuCl4(DMSO)(N-MeIm)][(N-MeIm)H] (N-MeIm=N-Methylimidazole, Compd.2) were synthesized. The influence of ligand structure (4-MeIm and N-MeIm) on hydrolytic mechanism-kinetics, electrochemical properties and solution stabilities of Ru-NAMI-A derivatives was studied by UV, NMR and cyclic voltammetry. The result shows that the 1st and 2nd chloro-hydrolysis as well as DMSO-hydrolysis mechanisms for two compounds are very similar to that for NAMI-A. However, the hydrolytic rates of Compd. 1 are obviously faster than that of Compd. 2, which means that introducing electron donating group (methyl) into imidazole ring (C4) of NAMI-A would accelerate hydrolytic reaction of Ru-NAMI-A derivatives. The stability of the complexes in acetic buffer solution is much more stable than that of in neural solution.

Key words: Ruthenium complex, Antimetastasis, Hydrolytic kinetics, Stabilities

TrendMD: