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Chem. J. Chinese Universities ›› 2009, Vol. 30 ›› Issue (9): 1703.

• Articles • Previous Articles     Next Articles

Research on Self-assembly MWNTs-clindamycin Molecularly Imprinted Sol-gel Electrochemical Sensor

HU Yu-Fang1, ZHANG Zhao-Hui1,2*, ZHANG Hua-Bin1, YU Xiao-Xiao1, YAO Shou-Zhuo2   

  1. 1. College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, China;
    2. State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, China
  • Received:2009-06-05 Online:2009-09-10 Published:2009-09-10
  • Contact: ZHANG Zhao-Hui. E-mail: zhaohuizhang77@hotmail.com
  • Supported by:

    湖南省自然科学基金(批准号: 08JJ4004)、湖南省教育厅优秀青年项目(批准号: 07B061)、化学生物传感与计量国家重点实验室开放基金和吉首大学研究生创新项目(批准号: JGY200901)资助.

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Abstract:

A novel electrochemical sol-gel imprinted sensor was developed via molecular imprinting technique, sol-gel technology and self-assembled membrane method, and thin film of molecularly imprinted sol-gel polymers with the specific binding sites for clindamycin was cast on MWNTs modified gold electrode by electropolymerization. The electrochemical performance and morphology of imprinted sol-gel film were charecterized by cyclic voltammetry(CV), differential pulse voltammetry(DPV), amperometric I-t curve and scanning electron microscope(SEM). The results show that the sensor has good selectivity and sensitivity, and the response to clindamycin on the MWNTs modified sol-gel imprinted sensor increases clearly. The linear range is over the range from 5.0×10-7— 8.0×10-5 mol/L, and the limit of detection is 2.44×10-8 mol/L. The sensor has been successfully employed to detect clindamycin in human urine.

Key words: Molecularly imprinted sol-gel; Multi-wall carbon nanotubes; Electrochemical sensor; Electropolymerization; Clindamycin

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