Synthesis and Biological Activities of 3-Substituent-5-aryloxazolidin-4-ones

Abstract

Abstract:

Mandipropamid is the first mandelamide fungicide on the market. Cyclizing open structures in a given structure represents one of the useful methods in the search for biologically active conformations. A series of novel 3-substituentphenethyl-5-aryloxazolidin-4-ones, the ring-closed analogues of mandipropamid, were obtained from the 2-hydroxy-N-(substitutedphenethyl)-2-arylacetamide and aldehydes by refluxing in benzene or toluene with catalytic amount of p-toluenesulphonic acid. Their structures were identified by means of elemental analysis, IR, ¹H NMR and MS spectra. And their structure-activity relationships were discussed.

Key words: Oxazolidinone, Mandelamide, Biological activity

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YAO Hong-Wei, LI Huan-Huan, SU Na-Na, WANG Hong-Xue, LIU Xing-Hai, ....... Synthesis and Biological Activities of 3-Substituent-5-aryloxazolidin-4-ones[J]. Chem. J. Chinese Universities, 2009, 30(5): 908.

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Synthesis and Biological Activities of 3-Substituent-5-aryloxazolidin-4-ones

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