Antibacterial Constituents from the Endophytic Fungus Penicillium sp. of Mangrove Plant Cerbera manghas

Chem. J. Chinese Universities

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Antibacterial Constituents from the Endophytic Fungus Penicillium sp. of Mangrove Plant Cerbera manghas

HAN Zhuang^1,2, MEI Wen-Li², CUI Hai-Bin^1,2, ZENG Yan-Bo², LIN Hai-Peng², HONG Kui², DAI Hao-Fu²*

1. Institute of Marine Biology, Shantou University, Shantou 515063, China;
2. Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China

Received:2007-08-20 Revised:1900-01-01 Online:2008-04-10 Published:2008-04-10
Contact: DAI Hao-Fu

Abstract

Abstract: To study the anti-bacterial constituents from endophytic fungus 093701 of mangrove plant Cerbera manghas, three compounds were isolated by column chromatography from the broth of endophytic fungus Penicillium sp. of Mangrove plant Cerbera manghas, and their structures were elucidated as 4-(3-hydroxybutan-2-yl)-3,6-dimethylbenzene-1,2-diol(1), 4-(3-hydroxybutan-2-yl)-3-acetyl-6-methylbenzene-1,2-diol(2), 3,4,5-trimethyl-1,2-benzenediol(3) by MS, NMR, ¹H-¹H COSY, HMQC, HMBC etc.. Among them, compounds 1 and 2 were new compounds, compound 3 was a new natural product. Bioassay results showed that compounds 1 and 3 possessed inhibitory effects on MRSA, while compound 2 had no anti-MRSA activity.

Key words: Mangrove plant, Endophytic fungus, Penicillium sp., Antibacterial, Chemical constituent

CLC Number:

O629

TrendMD:

HAN Zhuang^1,2, MEI Wen-Li², CUI Hai-Bin^1,2, ZENG Yan-Bo², LIN Hai-Peng², HONG Kui², DAI Hao-Fu²*. Antibacterial Constituents from the Endophytic Fungus Penicillium sp. of Mangrove Plant Cerbera manghas[J]. Chem. J. Chinese Universities, doi: .

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Antibacterial Constituents from the Endophytic Fungus Penicillium sp. of Mangrove Plant Cerbera manghas

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