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Studies on Paeoniflorin by Electrospray Ionization Tandem Mass Spectrometry

DONG Hong-Juan1,2, LIU Zhi-Qiang1, SONG Feng-Rui1, YU Zhan1, LI Hui-Lin1, LIU Shu-Ying1   

    1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun Center of Mass Spectrometry, Changchun 130022, China;
    2. Graduate School of the Chinese Academy of Sciences, Beijing 100049, China
  • Received:2005-12-05 Revised:1900-01-01 Online:2006-11-10 Published:2006-11-10
  • Contact: LIU Zhi-Qiang

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Abstract: Paeoniflorin was studied by using Electrospray Ionization Tandem Mass Spectrometry(ESI-MSn) both in positive and negative modes. Through the experimental method of hydrogen and deuterium exchange, the collision-induced dissociation fragmentation pathways were described and it proved that the precursor ion of paeoniflorin was clines to loss one molecule benzoic acid in both positive and negative MS2 spectra, furthermore, the loss of glucose residue was observed in positive ion mode, while, only one formaldehyde molecule loss from C-6 of glucose was observed in negative ion mode. The established method could be used for the sensitive and rapid identification of monoterpene glycoside in Paeonia albiflora.

Key words: Paeoniflorin, Electrospray Ionization Tandem Mass Spectrom etry(ESI-MSn), H/D exchange, Fragmentation mechanism

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