Studies on Synthesis of 2-Substituted-purine Derivatives

Abstract

Abstract: The Stille coupling reaction between 2-iodo-9-benzylpurine and RSnBu₃and the nucleophilic addition and cycloaddition of 2-vinyl-9-benzylpurine were studied. Aseries of new 2-substituted purined-erivatives were synthesized and characterized by elemental analysis, ¹HNMR, ¹³CNMR and MS. It was demonstrated that the reaction mechanism between 2-vinyl-9-benzylpurine and benzenethiol was oxidative addition rather than nucleophilic addition. The structure of the main product was determined by single-crystal X-ray method.

Key words: 2-Iodo-purine, 2-Vinyl-purine, Stille coupling, Nucleophilic addition, Cycloaddition

CLC Number:

R914.5

TrendMD:

LIU Fu-Sheng, YU Shi-Tao, GE Xiao-Ping, YANG Jin-Zong. Studies on Synthesis of 2-Substituted-purine Derivatives[J]. Chem. J. Chinese Universities, 2003, 24(9): 1592.

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Studies on Synthesis of 2-Substituted-purine Derivatives

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