Chem. J. Chinese Universities ›› 2000, Vol. 21 ›› Issue (1): 79.

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Reductive Cyclization Initiated by an NAD(P)H Model——Synthesis of 2,2-Disubstituted Indanes

WANG Hong-Yi1, LIU You-Cheng1,2, GUO Qing-Xiang2   

  1. 1. National Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, China;
    2. Departmentof Chemistry, Universityof Scienceand Technology of China, Hefei 230026, China
  • Received:1999-06-26 Online:2000-01-24 Published:2000-01-24

Abstract: A facile synthesis of 2,2-disubstituted idanes was achieved by the reductive cyclization of 1-(o-bromomethylphenyl)-2,2-disubstituted-ethylenes(electron-withdrawing substituents) with an NAD(P)H model, 1-benzyl-1,4-dihydronicotinamide, in yields from moderate to good. The study revealed that 1-benzyl-1,4-dihydronicotinamide can be used in synthetic organic chemistry as an effective reductant.

Key words: NAD(P)H model, Reductive cyclization, 2,2-Disubstituted indanes

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