Chem. J. Chinese Universities ›› 1999, Vol. 20 ›› Issue (6): 895.

• Articles • Previous Articles     Next Articles

Studies on the Syntheses of 3-(β-D-Xylopyranosyl)pyridazine and 3-(β-D-Xylopyranosyl)-4,5-dihydro-1H-6-pyridazinone

SUN De-Qun1, ZU Jing2, MA Ling-Tai2, ZHANG Li-He2   

  1. 1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041;
    2. School of Pharmaceutical Sciences, Beijing Medical University, Beijing, 100083
  • Received:1998-08-04 Online:1999-06-24 Published:1999-06-24

Abstract: New Cnucleoside analogues were synthesized via the key intermediate 2-(2',3'4'-tri-O-benzoyl-β-D-xylopyranosyl)-furan. The stability of the α-and β-isomer was described. The conversion of the furan ring into pyridazine ring was performed by Clauso-Kaas method to give 3-(β-D-xylopyranosyl)pyridazine and 3-(β-D-xylopyranosyl-4,5-dihydro-6(1H)-pyridazinone.

Key words: Pyridazine, Pyridazinone, C-Nucleoside

CLC Number: 

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