Studies on the Chiral Structure of Thiazolidine Ligands and Their Application to Asymmetric Hydrosllylation Of Acetophenone

Chem. J. Chinese Universities ›› 1998, Vol. 19 ›› Issue (11): 1763.

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Studies on the Chiral Structure of Thiazolidine Ligands and Their Application to Asymmetric Hydrosllylation Of Acetophenone

YAO Jin-Shui¹, XU Gui-Yun¹, Li Hong², He Bing-Lin²

1. Department of Chemical Engineering, Shangdong Institute of Light Industry, Jinan, 250100;
2. State Key Laboratory of Functional Polymetric Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin, 300071

Received:1997-11-21 Online:1998-11-24 Published:1998-11-24

Abstract

Abstract: The structure and optical activity of two thiazolidine ligands, 2-(2-pyridyl)-4-carbomethoxy-1,3-thiazolidine(A) and 2-methyl-2-(2-pyridyl)-4-carbomethoxy-1,3-thiazolidine(B), were reported in this paper. The diastereomers of Aand Bwere purified by fractional crystallization or column chromatography. The asymmetric hydrosilylation of acetophenone catalyzed by in situ catalysts prepared from Rh(COD)Cl₂ and ligand Aor Bwas investigated respectively. It was found that the cataytic reaction was only influenced by the chiral structure of C4 in thiazolidine, the chiral centre of C2 epimerized rapidly catalyzed by Rh(Ⅰ).

Key words: Thiazolidine, Chiral ligand, Asymmetric hydrosilylation

CLC Number:

O643

TrendMD:

YAO Jin-Shui, XU Gui-Yun, Li Hong, He Bing-Lin. Studies on the Chiral Structure of Thiazolidine Ligands and Their Application to Asymmetric Hydrosllylation Of Acetophenone[J]. Chem. J. Chinese Universities, 1998, 19(11): 1763.

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Studies on the Chiral Structure of Thiazolidine Ligands and Their Application to Asymmetric Hydrosllylation Of Acetophenone

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