Quantitative Structure-Activity Relationship Studyof Herbicidal α-Substituted Acetamides

Chem. J. Chinese Universities ›› 1995, Vol. 16 ›› Issue (5): 735.

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Quantitative Structure-Activity Relationship Studyof Herbicidal α-Substituted Acetamides

YANG Hua-Zheng, LI Quan-Zhong, CHENG Mu-Ru, REN Kang-Tai

Institute of Eleniento-Organic Chemistry, National Key Laboratory ofElernento-Organic Chemistry, Nankai University, Tianjin, 300071

Received:1994-05-30 Revised:1995-02-21 Online:1995-05-24 Published:1995-05-24

Abstract

Abstract: The quantitative relationship between the structures of N, N-disubstituted-α-chloroacetamide and α-(O,O-dialkyl phosphorodithioy) acetamide and their herbicidal activi ty on the barnyard grass,Echinochloa cruss-galli, was analyzed respectively. We found that their hydrophobicity and steric dimension of substituted amino group strongly affect their herbicidal activity. In two QSAR equations, the optimum steric dimension values (B₁) were approximate, but their optimum hydrophobicity values (π) differ from each other.It was suggested that there may be the same mode of action for the two kinds of compounds.

Key words: Substituted acetamide, Herbicidal activity, QSAR, Regression analysis

CLC Number:

O623.626

TrendMD:

YANG Hua-Zheng, LI Quan-Zhong, CHENG Mu-Ru, REN Kang-Tai. Quantitative Structure-Activity Relationship Studyof Herbicidal α-Substituted Acetamides[J]. Chem. J. Chinese Universities, 1995, 16(5): 735.

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Quantitative Structure-Activity Relationship Studyof Herbicidal α-Substituted Acetamides

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