Synthetic and Spectroscopic Studies on N-Ferrocenoyl-N'-Aryl (alkyl) thioureas

Chem. J. Chinese Universities ›› 1993, Vol. 14 ›› Issue (6): 801.

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Synthetic and Spectroscopic Studies on N-Ferrocenoyl-N'-Aryl (alkyl) thioureas

WANG Ji-Tao, ZHANG Yun-Wen, XU Yu-Ming, YUAN Yao-Feng, GAO Sheng-Hua

Department of Chemistry, Nankai University, Tianjin, 300071

Received:1992-10-04 Revised:1993-03-01 Online:1993-06-24 Published:1993-06-24

Abstract

Abstract: In this paper, ferrocenoyl isothiocyanate is synthesized for the first time.Without being separated, it reacts with various amines, such as heterocyclic amines, aliphatic amines with lower molecular weight, α-naphthyl amine and aromatic amines containing various substituted groups.Twenty one N-ferrocenoyl-N'-Ary (alkyl) thiourea derivatives have been obtained in good yields.They can be conveniently isolated and purified.At a low temperature (- 5-0℃), ferrocenoyl-isoth-iocyanate reacts with aqueous solutions of free amines (i.e.33% ethyl amine, 25% methyl amine) to form corresponding derivatives in fairly good yields.All the compounds have not been reported so far and their structures have been confirmed by elemental analysis, ¹H NMRand IR.

Key words: Ferrocenoyl isothiocyanate, Amines, Thiourea, Addition reaction

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WANG Ji-Tao, ZHANG Yun-Wen, XU Yu-Ming, YUAN Yao-Feng, GAO Sheng-Hua . Synthetic and Spectroscopic Studies on N-Ferrocenoyl-N'-Aryl (alkyl) thioureas[J]. Chem. J. Chinese Universities, 1993, 14(6): 801.

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Synthetic and Spectroscopic Studies on N-Ferrocenoyl-N'-Aryl (alkyl) thioureas

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