Chem. J. Chinese Universities ›› 2019, Vol. 40 ›› Issue (3): 456.doi: 10.7503/cjcu20180622

• Analytical Chemistry • Previous Articles     Next Articles

Three New Phenolic Compounds from Salacia cochinchinensis Lour and Their α-Glucosidase Inhibitory Activities

ZHANG Juanrong, YOU Huimei, JING Yuxing, ZHAO Jiaowen, WANG Wei, LIU Wenxing, ZHOU Min*(), JIANG Zhiyong*()   

  1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education,School of Ethnic Medicine, Yunnan Minzu University, Kunming 650500, China
  • Received:2019-09-10 Online:2019-01-12 Published:2019-01-12
  • Contact: ZHOU Min,JIANG Zhiyong E-mail:zhouminynun@163.com;jiangzy2010@163.com
  • Supported by:
    † Supported by the National Natural Science Foundation of China(No.81560708) and the Reserve Talent Project of Middle and Young Academic Leaders in Yunnan Province, China(No.2015HB050).

Abstract:

Five compounds were isolated from the stems and leaves of Salacia cochinchinensis Lour. By comprehensive spectroscopic analyses including mass spectroscopy(MS), infrared radiation(IR), 1D and 2D nuclear magnetic resonance(NMR) [heteronuclear single quantum coherence(HSQC), heteronuclear multiple bond correlation(HMBC), 1H-1H chemical-shift correlation spectroscopy(1H-1H COSY) and rotating frame overhauser effect spectroscopy(ROESY)], their structures were elucidated as Salaciacochinoside A(1), 5'-O-3,4,5-trimethoxybenzoyl-β-D-apiofuranoside(2), 5-methoxy-anticerol A(3), 21α,30-dihydroxy-D∶A-friedooleanan-3-one(4) and 21α,26-dihydroxyfriedelan-3-one(5), respectively. Compounds 1—3 were new compounds. All the compounds were assayed for the anti-diabetic activities. Compounds 1 and 3 exhibited remarkable bioactivity, inhibiting α-glucosidase with IC50 values of 0.32 and 0.59 μmol/L, respectively. Compounds 2, 4 and 5 showed none anti-diabetic activity in current experiment.

Key words: Salacia cochinchinensis, Phenolic compound, α-Glucosidase inhibitory activity;

CLC Number: 

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