CJCU

Chem. J. Chinese Universities ›› 2012, Vol. 33 ›› Issue (09): 1886.doi: 10.3969/j.issn.0251-0790.2012.09.002

• Letter • Previous Articles     Next Articles

Inhibition Effect of NIR Photothermal Therapy Mediated by Gold Nanoflowers on Proliferation of Human Laryngocarcinoma Hep-2 Cells

SONG Wen-Zhi1, JIANG Ya-Ping1, JI Xiao-Hui2, ZHAO Li-Li2, YIN Wan-Zhong3, YANG Wen-Sheng2   

  1. 1. China-Japan Union Hospital, Jilin University, Changchun 130033, China;
    2. College of Chemistry;
    3. The First Clinical Hospital, Jilin University, Changchun 130012, China
  • Received:2012-04-28 Online:2012-09-10 Published:2012-08-14

PDF (PC)

Cited

2

Abstract:

Citrate-capped gold nanoflowers(GNFs) prepared by seeding approach were identified to show efficiently photothermal conversion under the irradiation of 808 nm near-infrared laser. MTT results demonstrate that the photothermal therapy mediated by GNFs inhibits the proliferation of Hep-2 cells effectively, and the inhibition effect increases with the increased concentrations of GNFs and power of the laser. The results of apoptosis and necrosis tested by flow cytometry demonstrate that the photothermal ablation play a predominant role in suppressing the proliferation of the Hep-2 cells. Such citrate-capped GNFs are expected to be a kind of materials potential useful in tumuor NIR photothermal therapy.

Key words: Gold nanoflowers, Sodium citrate, Near-infrared photothermal therapy, Human laryngocarcinoma Hep-2 cell, Thermal ablation

CLC Number: 

TrendMD: