Characterization of Transformation Pattern of Baicalin Using UV Spectrometric Analysis and Multivariate Curve Resolution

doi:10.3969/j.issn.0251-0790.2012.07.015

Abstract

Abstract: Investigation of the transformation pattern of bacalin contributes to the quality control of scutellaria preparations. In this work, UV spectrometric method was used to record the UV spectra during transformation process of baicalin under different conditions. Multivariate curve resolution was utilized to analysis the spectra for resolving concentration and spectra profiles of the reactant species. The transformation kinetic profile of baicalin was evaluated as consecutive two-step one-order reaction. Transformation products were deduced by high performance liquid chromatography-tandem multistage mass spectrometric and time-of-flight mass spectrometric analysis of samples collected at different times during reaction process. The transformation products of baicalin included isomerides of baicalin, baicalein and dimmer of baicalein. The possible transformation pathway of baicalin was also inferred.

Key words: Baicalin, UV spectra, Multivariate curve resolution-alternating least square

CLC Number:

O657.32

TrendMD:

ZHENG Xin-Tian, QU Hai-Bin. Characterization of Transformation Pattern of Baicalin Using UV Spectrometric Analysis and Multivariate Curve Resolution[J]. Chem. J. Chinese Universities, 2012, 33(07): 1450.

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Characterization of Transformation Pattern of Baicalin Using UV Spectrometric Analysis and Multivariate Curve Resolution

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