Solidification of Superamolecule Ordering Assembly Liquid Phase Microextraction and Its Application for the Determination and Evaluation for Lignans Quality in Schisandra Chinensis(Turcz.) Baill

doi:10.3969/j.issn.0251-0790.2012.05.014

Abstract

Abstract: The extraction mechanism of solidification of superamolecule ordering assembly liquid phase microextraction(SSMOALPME) was proposed based on the change in the UV spectra of lignan compounds before and after the solidification of floating organic drop liquid phase microextraction(SFODLPME). SSMOALPME coupled with high performance liquid chromatography(HPLC) was introduced for the determination and eva-luation of five low abundance lignan compounds in Schisandra chinensis(Turcz.) Baill from different origins. Under the optimized parameters, the linear ranges of schisandrol A, schisantherin A, schizandrin A, schizandrin B and schizandrin C were 2.48×10^-3-6.21, 2.27×10^-3-28.5, 2.31×10^-3-28.8, 2.27×10^-3-5.69 and 1.05×10^-3-5.25 μg/mL, the limits of detection(LODs) were 0.4, 0.4, 0.4, 0.08 and 0.08 ng/mL, respectively, the intra and inter RSDs were less than 9.7%, the mean recoveries of analytes in traditional Chinese medicines(TCMs) were between 91.9% and 104.7%, and the enrichment factors(EFs) were in the range of 39-529 for SFODLPME. There was no significant difference in results determined lignan compounds in Schisandra chinensis(Turcz.) Baill by this method and Pharmacopoeia method (P=95%). SSMOALPME-HPLC provide the theoretic foundation and experimental evidence for reflecting bioactive component characteristics of multicomponent, multi-targets, synergistic effect, and establishing scientific quality control methods in TCMs.

Key words: Solidification of floating organic drop liquid phase microextraction(SFODLPME), Superamolecule ordering assembly, Enrichment factor, Schisandra chinensis(Turcz.) Baill, Lignan

CLC Number:

O657

TrendMD:

XUE Xue, ZHANG Hong-Fen, BAI Xiao-Hong, YUE Yuan. Solidification of Superamolecule Ordering Assembly Liquid Phase Microextraction and Its Application for the Determination and Evaluation for Lignans Quality in Schisandra Chinensis(Turcz.) Baill[J]. Chem. J. Chinese Universities, 2012, 33(05): 942.

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Solidification of Superamolecule Ordering Assembly Liquid Phase Microextraction and Its Application for the Determination and Evaluation for Lignans Quality in Schisandra Chinensis(Turcz.) Baill

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