广东石豆兰中的噁庚英和联苄类化合物

高等学校化学学报

广东石豆兰中的噁庚英和联苄类化合物

吴斌¹, 陈坚波², 何山¹, 潘远江¹

1. 浙江大学化学系, 杭州 310027;
2. 金华职业技术学院医学院, 金华 321000

收稿日期:2007-07-10 修回日期:1900-01-01 出版日期:2008-02-10 发布日期:2008-02-10
通讯作者: 潘远江

Oxepine and Bibenzyl Compounds from Bulbophyllum kwangtungense

WU Bin¹, CHEN Jian-Bo², HE Shan¹, PAN Yuan-Jiang¹*

1. Department of Chemistry, Zhejiang University, Hangzhou 310027, China;
2. College of Medicine, Jinhua College of Profession and Technology, Jinhua 321000, China

Received:2007-07-10 Revised:1900-01-01 Online:2008-02-10 Published:2008-02-10
Contact: PAN Yuan-Jiang

摘要/Abstract

摘要： 从兰科植物广东石豆兰(Bulbophyllum kwangtungense Schlecht.)的乙酸乙酯部分分离得到了2个新的茋类化合物5-(2,3-二甲氧苯乙基)-6-甲基苯并[d][1,3]二氧戊环(1)和10,11-二氢-2,7-二甲氧基-3,4-亚甲二氧基二苯并[b,f]噁庚英(2). 药理活性实验结果证明, 化合物2对体外培养的Hela细胞有较强的抑制作用.

关键词: 广东石豆兰, 二氢二苯噁庚英, 联苄类化合物

Abstract: Phytohemical investigation of the EtOAc extract of leaves and stems of Bulbophyllum kwangtungense Schlecht., belonging to the orchid family was carried out. Two new stilbenods were isolated by repeat column chromatography and characterized: one is bibenzyl compound, 5-(2,3-dimethoxyphenethyl)-6-methylbenzo[d][1,3]dioxole(1), and the other dibenz[b,f]oxepine, 10,11-dihydro-2,7-dimethoxy-3,4-methylene-dioxy dibenzo[b,f]oxepine(2). Their structures were established on the basis of analyses of spectroscopic evidence, particularly by two-dimensional NMR spectroscopic analysis. Bibenzyl compound with a methyl group in the benzene ring is rarely found from natural sources. Natural oxepines are very rare, and most of them were reported to have good anti-tumor activities. In addition, anti-tumor activities of the new compounds were also evaluated. Among the compounds isolated, compound 2 showed anti-tumor activities with IC₅₀ value of 47.2 μg/mL in vitro against cultures of Hela cells.

Key words: Bulbophyllum kwangtungense, Oxepine, Bibenzyl compound

中图分类号:

O629.9

TrendMD:

吴斌,陈坚波,何山,潘远江 . 广东石豆兰中的噁庚英和联苄类化合物. 高等学校化学学报, doi: .

WU Bin¹, CHEN Jian-Bo², HE Shan¹, PAN Yuan-Jiang¹*. Oxepine and Bibenzyl Compounds from Bulbophyllum kwangtungense. Chem. J. Chinese Universities, doi: .