羟基磷灰石在磺化聚醚苯并咪唑薄膜表面的生长

高等学校化学学报 ›› 2010, Vol. 31 ›› Issue (1): 1.

羟基磷灰石在磺化聚醚苯并咪唑薄膜表面的生长

黄霞芸¹, 史子兴¹, 印杰^1,2

1. 上海交通大学化学化工学院,
2. 金属基复合材料国家重点实验室, 上海 200240

收稿日期:2009-07-03 出版日期:2010-01-10 发布日期:2010-01-10
通讯作者: 史子兴, 男, 博士, 副教授, 主要从事聚合物基杂化材料和耐热杂环高聚物的设计与合成研究. E-mail: zxshi@sjtu.edu.cn
基金资助:
国家自然科学基金(批准号: 50973062)资助.

Growth of Hydroxyapatite on Sulfonated Polybenzimidazole Membranes

HUANG Xia-Yun¹, SHI Zi-Xing^1*, YIN Jie^1,2

1. School of Chemistry and Chemical Technology,
2. State Key Laboratory of Metal Matrix Composites, Shanghai Jiaotong University, Shanghai 200240, China)

Received:2009-07-03 Online:2010-01-10 Published:2010-01-10
Contact: SHI Zi-Xing. E-mail: zxshi@sjtu.edu.cn
Supported by:
国家自然科学基金(批准号: 50973062)资助.

摘要/Abstract

摘要：

以聚[2,2′-(对氧基联苯)-5,5′-苯并咪唑](OPBI)及其磺化产物磺化聚[2,2′-(对氧基联苯)-5,5′-苯并咪唑](SOPBI)薄膜作为基体, 采用交替沉积和模拟体液(SBF)浸泡相结合的方法快速在薄膜表面沉积羟基磷灰石层. 采用选区电子衍射(SAED)和衰减全反射傅里叶变换红外光谱(ATR-FTIR)对羟基磷灰石(HA)的晶体结构进行了分析. 用扫描电子显微镜(SEM)对整个沉积过程中羟基磷灰石的形态变化进行了跟踪. 实验结果表明, SOPBI薄膜诱导HA沉积的速率明显快于OPBI薄膜. SOPBI的磺酸基团不但提供了固定Ca²⁺的负电表面, 而且还有助于咪唑基团对Ca²⁺的固定. 而缺失磺酸基团的OPBI在不同pH值的交替沉积溶液中的电离形式阻碍了咪唑基团对Ca²⁺和HPO₄^2-的作用, 且未能在SBF浸泡过程中得到改善.

关键词: 羟基磷灰石; 磺化聚醚苯并咪唑; 交替沉积

Abstract:

Organic polymer coated with hydroxyapatite(HA) is an attractive material for the development of tissue repairing application. The abilities of hydroxyapatite incubation on poly [2,2′-(p-oxydiphenylene)-5,5′-bibenzimidazole](OPBI) and sulfonated poly[2,2′-(p-oxydiphenylene)-5,5′-bibenzimidazole](SOPBI) membranes were investigated with the combination of alternate soaking process and simulated body fluid(SBF) soaking methods. Hydroxyapatite phase was analyzed by SAED and ATR-FTIR method. Morphology changes of the hydroxyapatite were observed by SEM. The results show that the use of the SOPBI membranes leads to a higher hydroxyapatite formation rate than that of the OPBI membranes. The sulfonic groups of SOPBI membranes not only offer a negative charged surface to attract Ca²⁺ but also help imidazole groups to bind Ca²⁺. In comparison, OPBI membranes without sulfonic groups decrease formation ability of hydroxyapatite because protonation types of imidazole groups in alternate soaking solutions inhibit interaction between imidazole and Ca²⁺ and HPO₄^2-, which can not be improved by the subsequent SBF soaking.

Key words: Hydroxyapatite; Poly [2,2′-(p-oxydiphenylene)-5,5′-bibenzimidazole]; Alternate soaking

TrendMD:

黄霞芸, 史子兴, 印杰. 羟基磷灰石在磺化聚醚苯并咪唑薄膜表面的生长. 高等学校化学学报, 2010, 31(1): 1.

HUANG Xia-Yun, SHI Zi-Xing*, YIN Jie. Growth of Hydroxyapatite on Sulfonated Polybenzimidazole Membranes. Chem. J. Chinese Universities, 2010, 31(1): 1.

参考文献

[1]Yamaguchi I., Itoh S., Suzuki M., et al.. Biomaterials[J], 2003, 24: 3285—3292
[2]Kawai T., Ohtsuki C., Kamitakahara M., et al.. Biomaterials[J], 2004, 25: 4529—4534
[3]Wang X., Li Y., Wei J., et al.. Biomaterials[J], 2002, 23: 4787—4791
[4]Bajpai K. A., Singh R.. Polym. Int.[J], 2007, 56: 557—568
[5]Tanahashi M., Matsuda T.. J. Biomed. Mater. Res.[J], 1997, 34: 305—315
[6]Putnam D., Gentry C. A., Pack D. W., et al.. Proc. Natl. Acad. Sci.[J], 2001, 98: 1200—1205
[7]Schachschal S., Pich A., Adler H. J.. Langmuir[J], 2008, 24: 5129—5134
[8]Li Q., Jensen J. O., Savinell R. F., et al.. Prog. Polym. Sci.[J], 2009, 34: 449—477
[9]Xu H., Chen K., Guo X., et al.. Polymer[J], 2007, 48: 5556—5564
[10]Kokubo T., Kushitani H., Sakka S., et al.. J. Biomed. Mater. Res.[J], 1990, 24: 721—734
[11]Taguchi T., Kishida A., Akashi M.. Chem. Lett.[J], 1998, 27: 711—712
[12]Oyane A., Uchida M., Choong C., et al.. Biomaterials[J], 2005, 26: 2407—2413
[13]Mitsuru U., Masaki S., Amane M.. Macromolecules[J], 1985, 18: 2723—2726
[14]Kokubo T., Takadama H.. Biomaterials[J], 2006, 27: 2907—2915
[15]Kim H. M., Himeno T., Kokubo T., et al.. Biomaterials[J], 2005, 26: 4366—4373
[16]Zhu P., Masuda Y., Yonezawa T., et al.. J. Am. Ceram. Soc.[J], 2003, 86: 782—872
[17]Elliot J. C.. Structure and Chemistry of the Apatites and Other Calcium Phosphates[M], Amsterdam: Elsevier Science BV, 1994: 1—61
[18]Leonor L. B., Kim H. M., Balas F., et al.. J. Mater. Sci.: Mater. Med.[J], 2007, 18: 1923—1930
[19]Miyazaki T., Imamura M., Ishida E., et al.. J. Mater. Sci.: Mater. Med.[J], 2009, 20: 157—161
[20]Leonor I. B., Kim H. M., Balas F., et al.. J. Mater. Chem.[J], 2007, 17: 4057—4063
[21]Cao P., Gu R., Tian Z.. J. Phys. Chem. B[J], 2003, 107: 769—777
[22]Taguchi T., Muraoka Y., Matsuyama H., et al.. Biomaterials[J], 2001, 22: 53—58
[23]Li B., Wang Y., Jia D., et al.. Biomed. Mater.[J], 2009, 4: 015011—015017
[24]Schechter A., Savinell F. R.. Solid State Ionics[J], 2002, 147: 181—187