聚环氧乙烷-g-聚己内酯两亲性接枝共聚物的合成及药物释放行为

高等学校化学学报 ›› 2009, Vol. 30 ›› Issue (11): 2291.

聚环氧乙烷-g-聚己内酯两亲性接枝共聚物的合成及药物释放行为

毛静^1,2, 甘志华¹

1. 中国科学院化学研究所, 北京 100190;
2. 中国科学院研究生院, 北京 100049

收稿日期:2009-04-21 出版日期:2009-11-10 发布日期:2009-11-10
通讯作者: 甘志华, 男, 博士, 研究员, 博士生导师, 主要从事环境友好和生物相容高分子材料的研究. E-mail: zhgan@iccas.ac.cn
基金资助:
国家自然科学基金(批准号: 50830103, 50521302)资助.

Synthesis and Controlled Drug Release of Amphiphilic Graft Copolymers PEO-b-PGL-g-PCL

MAO Jing^1,2, GAN Zhi-Hua^1*

1. Institute of Chemistry, Chinese Academy of Sciences(CAS), Beijing 100190, China;
2. Graduate University of Chinese Academy of Sciences, Beijing 100049, China

Received:2009-04-21 Online:2009-11-10 Published:2009-11-10
Contact: GAN Zhi-Hua. E-mail: zhgan@iccas.ac.cn
Supported by:
国家自然科学基金(批准号: 50830103, 50521302)资助.

摘要/Abstract

摘要：

通过环氧丙醇(GL)与环氧乙烷(EO)的阴离子顺序开环聚合制备了水溶性嵌段共聚物PEO-b-PGL, 以PGL嵌段每个重复单元的侧羟基为引发点进一步引发ε-己内酯(CL)的开环聚合, 合成了结构规整的以聚环氧乙烷(PEO)为主链的两亲性接枝共聚物(PEO-b-PGL-g-PCL). 研究了PEO-b-PGL-g-PCL在水相中的自组装行为, 采用稳态荧光探针法测定了胶束的临界胶束浓度(cmc). 以疏水性药物阿霉素(DOX)为模型药物, 研究了两亲性接枝共聚物的化学组成对药物的扩散释放以及降解释放行为的影响.

关键词: 两亲性接枝共聚物; 聚环氧乙烷; 聚己内酯; 自组装; 药物释放

Abstract:

Water-soluble diblock copolymers PEO-b-PGL with well controlled composition were synthesized by sequential anionic ring-opening copolymerization of ethylene oxide(EO) and glycidol(GL). ε-Caprolactone(CL) was further initiated by the pendant hydroxyl group of each GL unit in PEO-b-PGL copolymer to synthesize amphiphilic graft copolymers PEO-b-PGL-g-PCL with well defined grafting architecture. The self-assembly behavior of PEO-b-PGL-g-PCL graft copolymers was investigated with pyrene as a probe for the determination of critical micelle concentrations(cmc). Meanwhile, doxorubicin as a model drug was encapsulated into PEO-b-PGL-g-PCL micelles, and its release behavior controlled by diffusion and enzymatic degradation was stu-died. The influences of composition and grafting structure in PEO-b-PGL-g-PCL copolymers on self-assembly, drug loading and release were discussed.

Key words: Amphiphilic graft copolymer; Poly(ethylene oxide); Poly(ε-caprolactone); Self-assembly; Drug release

TrendMD:

毛静, 甘志华. 聚环氧乙烷-g-聚己内酯两亲性接枝共聚物的合成及药物释放行为. 高等学校化学学报, 2009, 30(11): 2291.

MAO Jing, GAN Zhi-Hua*. Synthesis and Controlled Drug Release of Amphiphilic Graft Copolymers PEO-b-PGL-g-PCL. Chem. J. Chinese Universities, 2009, 30(11): 2291.