高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

DNA序列编码及相似度计算

张宝华, 王海水, 许禄   

  1. 中国科学院长春应用化学研究所, 长春 130022
  • 收稿日期:2006-01-18 修回日期:1900-01-01 出版日期:2006-12-10 发布日期:2006-12-10
  • 通讯作者: 许禄

Codes of DNA Primary Sequences and the Similarity Calculation

ZHANG Bao-Hua, WANG Hai-Shui, XU Lu   

  1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  • Received:2006-01-18 Revised:1900-01-01 Online:2006-12-10 Published:2006-12-10
  • Contact: XU Lu

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被引次数

14

摘要： 将DNA的一级序列如β-球蛋白基因的第一个外显子(Exon)转化为分子“结构图”, 然后由所得“结构图”提取图的不变量, 如分子连接性指数. 以图的不变量作为自变量, 再由相似度计算公式或距离公式进行相似度计算, 其相似度的大小显示不同物种间亲缘关系的远近程度. 运用这种方法对人、 猴及鼠等8个物种的β-球蛋白基因的第一个外显子的相似度进行计算, 所得结果与生物学中的进化树符合得较好.

关键词: DNA序列, 外显子, 分子连接性指数, 相似度比较, 进化树

Abstract: The first exon of DNA primary sequence such as β-globin gene was translated into “structure graph” based on the rules suggested in this paper. Then the invariants, such as molecular connectivity indices, were extracted from those graphic representations of DNA primary sequences, and used to calculate the similarities among the ten species. From these similarities/dissimilarities the homologies can be revealed that they are in agreement]with the phylogenetic tree satisfactorily.

Key words: DNA primary sequence, Exon, Molecular connectivity index, Similarity comparison, Phylogenetic tree

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