高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 166.

• Chemistry in Life Sciences • 上一篇    下一篇

Imaging Cholesterol Vesicles Aggregation in Bile Models

LI Guang-Ming1, ZHANG Ying2, GAN Li-Hua2, WANG Pei-Jiao2, CHEN Long-Wu2   

  1. 1. Institute of Technology, Tongji University, Shanghai 200092;
    2. Department of Chemistry, Scientific School, Tongji University, Shanghai 200092
  • 出版日期:2000-12-31 发布日期:2000-12-31
  • 基金资助:

    Supported by fund of scientific research of Shanghai education committee.

Imaging Cholesterol Vesicles Aggregation in Bile Models

LI Guang-Ming1, ZHANG Ying2, GAN Li-Hua2, WANG Pei-Jiao2, CHEN Long-Wu2   

  1. 1. Institute of Technology, Tongji University, Shanghai 200092;
    2. Department of Chemistry, Scientific School, Tongji University, Shanghai 200092
  • Online:2000-12-31 Published:2000-12-31
  • Supported by:

    Supported by fund of scientific research of Shanghai education committee.

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摘要：

Investigation of aggregation of cholesterol vesicles is essential for the understanding of gallstones prior to the appearance of cholesterol monohydrate crystals. In this article, according to existing data based on various microscopic techniques and present data on various microstructural pathways leading to cholesterol crystal formation in bile models, we considered the bile models composed of cholesterol, bile salts and lecithin and distilled water and employed light polarization microscopy and microelectrophoresis apparatus. Concentrated isotropic solutions of bile models were diluted to induce cholesterol supersaturation and start an evolution of microstructures, leading to cholesterol crystallization.

Abstract:

Investigation of aggregation of cholesterol vesicles is essential for the understanding of gallstones prior to the appearance of cholesterol monohydrate crystals. In this article, according to existing data based on various microscopic techniques and present data on various microstructural pathways leading to cholesterol crystal formation in bile models, we considered the bile models composed of cholesterol, bile salts and lecithin and distilled water and employed light polarization microscopy and microelectrophoresis apparatus. Concentrated isotropic solutions of bile models were diluted to induce cholesterol supersaturation and start an evolution of microstructures, leading to cholesterol crystallization.

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