高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 163.

• Chemistry in Life Sciences • 上一篇    下一篇

Three Dimensional Quantitative Structure Activity Relationship of Hept Analogs as HIV-1 Reverse Transcriptase Inhibitors

MENG Ge, CHEN Fen-Er   

  1. Department of Chemistry, Fudan University, Shanghai 200433
  • 出版日期:2000-12-31 发布日期:2000-12-31

Three Dimensional Quantitative Structure Activity Relationship of Hept Analogs as HIV-1 Reverse Transcriptase Inhibitors

MENG Ge, CHEN Fen-Er   

  1. Department of Chemistry, Fudan University, Shanghai 200433
  • Online:2000-12-31 Published:2000-12-31
  • Contact: 21

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摘要：

The discovery of the crystal structure of HIV-1 reverse transcriptase (RT) provides a new clear target for designing anti HIV drugs with less side effects. 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)-thymine (HEPT)and its analogs are selective HIV-RT linhibitors. Chemists carried out extensive studies on the modification of HEPT and provided a lot of data on biological activity of its analogs. In this paper 35 HIV-1RT inhibitors were selected from literature[1] and investigated by CoMFA method[2] for QSAR study.

Abstract:

The discovery of the crystal structure of HIV-1 reverse transcriptase (RT) provides a new clear target for designing anti HIV drugs with less side effects. 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)-thymine (HEPT)and its analogs are selective HIV-RT linhibitors. Chemists carried out extensive studies on the modification of HEPT and provided a lot of data on biological activity of its analogs. In this paper 35 HIV-1RT inhibitors were selected from literature[1] and investigated by CoMFA method[2] for QSAR study.

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