高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 122.

• Chemistry in Energy Sciences • 上一篇    下一篇

Studies of Cephalosporin C Purification by Ultrafitration

LI Chun-Yan1,2, HE Xu-Min1, FANG Fu-Lin3, LAN Wei-Guang1,3, XIA Hai-Ping1   

  1. 1. Department of Materials Science, Xiamen University, Xiamen 361005;
    2. Department of Chemistry, Fujian Medical University, Fuzhou 350004;
    3. Xiamen University Suntar Membrane Sci-technology Co. Ltd, Xiamen 361006
  • 出版日期:2000-12-31 发布日期:2000-12-31

Studies of Cephalosporin C Purification by Ultrafitration

LI Chun-Yan1,2, HE Xu-Min1, FANG Fu-Lin3, LAN Wei-Guang1,3, XIA Hai-Ping1   

  1. 1. Department of Materials Science, Xiamen University, Xiamen 361005;
    2. Department of Chemistry, Fujian Medical University, Fuzhou 350004;
    3. Xiamen University Suntar Membrane Sci-technology Co. Ltd, Xiamen 361006
  • Online:2000-12-31 Published:2000-12-31
  • Contact: d:\PDF\.pdf

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摘要：

Cephalosporin C was produced with fermentation technique. There are many impurities (mycelium, protein et al) in its fermentation liquor, which can be removed by ultrafitration membrane separation. The ultrafiltration technique has been used for purifying the fermentation liquid of antibiotics[1-2],however, its application in extraction of Cephalosporin C from its fermentation liquor has not been reported. In this paper, we use Ultra-flo ultraflitration membrane system (concludes UF-54 pilot plant, flat board membrane module, thin composite membrane of 30 thousand reject molecular weight) to purify #1-#3 fermentation liquors of Cephalosporin C, which were not pretreated except acidification(pH=3).

Abstract:

Cephalosporin C was produced with fermentation technique. There are many impurities (mycelium, protein et al) in its fermentation liquor, which can be removed by ultrafitration membrane separation. The ultrafiltration technique has been used for purifying the fermentation liquid of antibiotics[1-2],however, its application in extraction of Cephalosporin C from its fermentation liquor has not been reported. In this paper, we use Ultra-flo ultraflitration membrane system (concludes UF-54 pilot plant, flat board membrane module, thin composite membrane of 30 thousand reject molecular weight) to purify #1-#3 fermentation liquors of Cephalosporin C, which were not pretreated except acidification(pH=3).

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