高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 460.

• Physical Organic Chemistry • 上一篇    下一篇

An ab initio Research on the Pentacoordinate Carboxylic-phosphoric Anhydride

ZHONG Rugang1,2, LI Zhao-Long1, ZHAO Yu-Fen1, DAI Qianhuan2   

  1. 1. Bioorganic Phosphorus Chemistry Laboratory, Department of Chemistry Tsinghua University, Beijing 100084;
    2. Center for Chemistry and Bioengineering of Cancer Research, Beijing Polytechnic University, Beijing 100022
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 基金资助:
    National Natural Science Foundation of China (Grant No. 29632004)

An ab initio Research on the Pentacoordinate Carboxylic-phosphoric Anhydride

ZHONG Rugang1,2, LI Zhao-Long1, ZHAO Yu-Fen1, DAI Qianhuan2   

  1. 1. Bioorganic Phosphorus Chemistry Laboratory, Department of Chemistry Tsinghua University, Beijing 100084;
    2. Center for Chemistry and Bioengineering of Cancer Research, Beijing Polytechnic University, Beijing 100022
  • Online:1998-12-31 Published:1998-12-31
  • Supported by:
    National Natural Science Foundation of China (Grant No. 29632004)

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摘要： It is well known that phosphorylated peptides involve in a lot of biological processes, such as metabolism, membrane transportation, muscle contractility,cell cycle control, and so on[1] Some recent researches revealed a new respect of this kind of compounds. An N-phosporyl-α-amino acid can react with an n-peptide to form an 1(n+l)-peptide and react with an n-(desoxy-)ribotide to form an (n+1)-(desoxy-)ribotide in aqueous solution at about 38℃, as shown in Fig.1. However, N-phosporyl-β-amino acids can not react with the same substrates at the same conditional[2].

Abstract: It is well known that phosphorylated peptides involve in a lot of biological processes, such as metabolism, membrane transportation, muscle contractility,cell cycle control, and so on[1] Some recent researches revealed a new respect of this kind of compounds. An N-phosporyl-α-amino acid can react with an n-peptide to form an 1(n+l)-peptide and react with an n-(desoxy-)ribotide to form an (n+1)-(desoxy-)ribotide in aqueous solution at about 38℃, as shown in Fig.1. However, N-phosporyl-β-amino acids can not react with the same substrates at the same conditional[2].

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