高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

一种基于DAD二极管阵列检测器技术的中药指纹图谱方法

汤宏敏1,2, 罗永明2, 鄢燕1,2, 梁琼麟1, 孟宪生1, 罗国安1   

    1. 清华大学中药现代化研究中心, 北京 100084;
    2. 江西中医学院, 南昌 330004
  • 收稿日期:2008-04-03 修回日期:1900-01-01 出版日期:2009-02-10 发布日期:2009-02-10
  • 通讯作者: 罗国安, 梁琼麟

Research Method of Traditional Chinese Medicine Fingerprint Based on Diode-array Detector

TANG Hong-Min1,2, LUO Yong-Ming2, YAN Yan1,2, LIANG Qiong-Lin1*, MENG Xian-Sheng1, LUO Guo-An1*   

    1. Research Center of Traditional Chinese Herbal Medicine, Tsinghua University, Beijing 100084, China;
    2. Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
  • Received:2008-04-03 Revised:1900-01-01 Online:2009-02-10 Published:2009-02-10
  • Contact: LUO Guo-An, LIANG Qiong-Lin

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被引次数

13

摘要： 用HPLC/DAD分别建立血府逐瘀口服液单波长指纹图谱和最大吸收指纹图谱, 对比两者峰数量和面积的变化情况, 采用药典委员会2004A版相似度软件评价两种方法的差异. 结果表明, 最大吸收指纹图谱比单波长指纹图谱或多波长指纹图谱更能全面地反映血府逐瘀口服液的色谱峰信息, 并且相似度结果差异明显. 该方法信息量大, 中药的整体性、宏观性及复杂性分析相适应.

关键词: 中药指纹图谱, 最大吸收指纹图谱, 血府逐瘀口服液, 相似度

Abstract: Develop a new fingerprint method to research Xuefu Zhuyu oral liquid. By the use of the technology of HPLC/DAD, developing the single absorb wavelength fingerprint and the largest absorb fingerprint, using the software “Similarity Evaluation System for Chromatographic Fingerprint of traditional chinese medicine(TCM)” edited by the commission of state phamacopoeia. The variation of common peaks area and number of peaks between the single absorb wavelength fingerprint and the largest absorb fingerprint. The largest absorb fingerprint can reflect all the chromatographic peak imformation of Xuefu Zhuyu oral liquid, and the similarity is also different.The new method embody the thinking of maximum imformation, accommodating the integrity, macroscopical character and complex characters of TCM.

Key words: Fingerprint of traditional Chinese medicine(TCM), Largest absorb fingerprint of TCM, Xuefu Zhuyu oral liquid, Similarity

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