高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 42.
• Organic Synthesis Chemistry • 上一篇 下一篇
戴偉民, 李玉霞
DAI Wei-Min, LEE Mavis Yuk Ha
摘要: Enediynes are a novel class of naturally occurring antitumor antibiotics capable of causing DNA strand cleavage by hydrogen atom abstraction from the deoxyribose backbone. During the past decade, numerous synthetic methods have been developed to synthesize the naturally occurring and the "designed" enediynes for biomedical studies. Recently, we have succeeded in assembling the cis-enediynes 2 by a novel and high-yielding allylic rearrangement under mild reaction conditions (Eq 1).1-3 This methodology has been used to synthesize a 10-membered ring enediyne3 which exhibits DNA cleavage activity.
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