高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 260.

• Organic Synthesis Chemistry • 上一篇    下一篇

A New Procedure for Preparing 7-Nitro-l,3-benzodioxane and Its Application in the Synthesis of Phosphonates

Li Chunbao, Wang Yonghuei, Wang Tianyu, Li Nan, Yu Zhifang   

  1. Department of Chemistry, Tianjin University, Tianjin 300072
  • 出版日期:1998-12-31 发布日期:1998-12-31

A New Procedure for Preparing 7-Nitro-l,3-benzodioxane and Its Application in the Synthesis of Phosphonates

Li Chunbao, Wang Yonghuei, Wang Tianyu, Li Nan, Yu Zhifang   

  1. Department of Chemistry, Tianjin University, Tianjin 300072
  • Online:1998-12-31 Published:1998-12-31

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摘要： The reproducible yield of 7-nitro-1,3-benzodioxane (2) from the reaction of 3-nitrophenol and 40% formaldehyde catalyzed by sulfuric acid is less than 1%[1]. By replacing formaldehyde with triformol, followed by treatment of the crude product with 10% NaOH solution, we have improved the yield to 12%. An orthogonal design experiment was carried out to optimize the conditions[2].

Abstract: The reproducible yield of 7-nitro-1,3-benzodioxane (2) from the reaction of 3-nitrophenol and 40% formaldehyde catalyzed by sulfuric acid is less than 1%[1]. By replacing formaldehyde with triformol, followed by treatment of the crude product with 10% NaOH solution, we have improved the yield to 12%. An orthogonal design experiment was carried out to optimize the conditions[2].

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