高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 317.

• Organic Synthesis Chemistry • 上一篇    下一篇

Thiophenes from Dienediones

Chi Wi Ong1, Po Chuen Shieh2   

  1. 1. Department of Chemistry, National Sun Yat Sen University, Kaoshiung, Taiwan;
    2. Department of Pharmacy, Tajen Pharmaceutical Junior College, Ping Tung, Taiwan
  • 出版日期:1998-12-31 发布日期:1998-12-31

Thiophenes from Dienediones

Chi Wi Ong1, Po Chuen Shieh2   

  1. 1. Department of Chemistry, National Sun Yat Sen University, Kaoshiung, Taiwan;
    2. Department of Pharmacy, Tajen Pharmaceutical Junior College, Ping Tung, Taiwan
  • Online:1998-12-31 Published:1998-12-31

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摘要： Our previous studies have demonstrate the usefulness of dienedione as versatile intermediates for the synthesis of cyclopentenone and arylfuran. The dienedione moiety may serve as a four carbon unit which can undergo consecutive nucleophilic addition reaction to form heterocycles. Herein we report our investigation on the addition of sulfur to the four carbon unit of dienedione for the synthesis of 2,5-disubstituted thiophenes. The regioselectivity of the reaction under various conditions will also be discussed.

Abstract: Our previous studies have demonstrate the usefulness of dienedione as versatile intermediates for the synthesis of cyclopentenone and arylfuran. The dienedione moiety may serve as a four carbon unit which can undergo consecutive nucleophilic addition reaction to form heterocycles. Herein we report our investigation on the addition of sulfur to the four carbon unit of dienedione for the synthesis of 2,5-disubstituted thiophenes. The regioselectivity of the reaction under various conditions will also be discussed.

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