高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 310.

• Organic Synthesis Chemistry • 上一篇    下一篇

Synthetic and Conformational Studies of Bridged β-Cyclodextrin Dimers

Xiao-Qi Zheng1, Qing-Xiang Guo2, Li Yang1, You-Cheng Liu1,2   

  1. 1. National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000;
    2. Department of Chemistry, University of Science and Technology of China, Hefei 230026
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 基金资助:
    This work was supported by the National Natural Science Foundation of China

Synthetic and Conformational Studies of Bridged β-Cyclodextrin Dimers

Xiao-Qi Zheng1, Qing-Xiang Guo2, Li Yang1, You-Cheng Liu1,2   

  1. 1. National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000;
    2. Department of Chemistry, University of Science and Technology of China, Hefei 230026
  • Online:1998-12-31 Published:1998-12-31
  • Supported by:
    This work was supported by the National Natural Science Foundation of China

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摘要： Cyclodextrins (CD) have been found wide applications in the artificial enzymes[1] due to their ability of recognizing and binding a variety of organic and inorganic substrates in aqueous solution. In some cases, however, their binding capacity and selectivity are not good enough to make them useful (Ka~102-104L/mol). Breslow et.al[2,3] have reported that the bridged cyclodextrin dimers can complex some kinds of substrates strongly (Ka~106-1011L/mol) because of their more recognition sites. Recently, we synthesized a series of bridged β-CD dimers. It has been observed that the conformation of the dimers changed markedly upon the solvents.

Abstract: Cyclodextrins (CD) have been found wide applications in the artificial enzymes[1] due to their ability of recognizing and binding a variety of organic and inorganic substrates in aqueous solution. In some cases, however, their binding capacity and selectivity are not good enough to make them useful (Ka~102-104L/mol). Breslow et.al[2,3] have reported that the bridged cyclodextrin dimers can complex some kinds of substrates strongly (Ka~106-1011L/mol) because of their more recognition sites. Recently, we synthesized a series of bridged β-CD dimers. It has been observed that the conformation of the dimers changed markedly upon the solvents.

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