高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 20.

• Plenary, Keynote and Invited Lectures • 上一篇    下一篇

Bile Acid Derivatives in the Preparation of New Synthetic Polymers

X. X. Zhu, H. Y. Liu, A. Benrebouh, S. Gouin, Y. H. Zhang   

  1. Department of Chemistry, University of Montreal C. P. 6128, Succursale Centre-ville, Montreal, Quebec, Canada H3C 3J7
  • 出版日期:1998-12-31 发布日期:1998-12-31

Bile Acid Derivatives in the Preparation of New Synthetic Polymers

X. X. Zhu, H. Y. Liu, A. Benrebouh, S. Gouin, Y. H. Zhang   

  1. Department of Chemistry, University of Montreal C. P. 6128, Succursale Centre-ville, Montreal, Quebec, Canada H3C 3J7
  • Online:1998-12-31 Published:1998-12-31

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摘要： Bile acids are compounds stored in the gallbladder and help in the digestion of fats and lipids in the gastro-intestinal tract. These amphiphilic compounds can interact favorably with both hydrophilic and hydrophobic molecules. To improve the biocompatibility of the polymers used in biomedical and pharmaceutical applications, we have synthesized various derivatives of bile acids and used them in the preparation of new polymeric materials, including both polyaddition and polycondensation products. The use of the bile acid derivatives should improve the biocompatibility of the polymers, especially when they are used in the gastrointestinal tract. Even in case of decomposition, these derivatives are not expected to cause serious problems of toxicity. We have used bile acids in the preparation of both stable polymers (hydrogels) and degradable ones (polyanhydrides).

Abstract: Bile acids are compounds stored in the gallbladder and help in the digestion of fats and lipids in the gastro-intestinal tract. These amphiphilic compounds can interact favorably with both hydrophilic and hydrophobic molecules. To improve the biocompatibility of the polymers used in biomedical and pharmaceutical applications, we have synthesized various derivatives of bile acids and used them in the preparation of new polymeric materials, including both polyaddition and polycondensation products. The use of the bile acid derivatives should improve the biocompatibility of the polymers, especially when they are used in the gastrointestinal tract. Even in case of decomposition, these derivatives are not expected to cause serious problems of toxicity. We have used bile acids in the preparation of both stable polymers (hydrogels) and degradable ones (polyanhydrides).

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