高等学校化学学报

高等学校化学学报 ›› 2013, Vol. 34 ›› Issue (2): 462.doi: 10.7503/cjcu20120639

• 高分子化学 • 上一篇    下一篇

磁性蛋白质微胶囊的声化学法构筑

王春蕾1,2, 闫俊涛1,2, 钟双玲3, 李占锋1, 崔学军1, 王洪艳1   

  1. 1. 吉林大学化学学院, 长春130012;
    2. 武汉工业学院化学与环境工程学院, 武汉 430023;
    3. 吉林农业大学资源与环境学院, 长春130118
  • 收稿日期:2012-07-06 出版日期:2013-02-10 发布日期:2013-01-21
  • 通讯作者: 崔学军,男,副教授,主要从事生物医用材料研究.E-mail:cui_xj@jlu.edu.cn;王洪艳,女,教授,博士生导师,主要从事生物医用材料研究.E-mail:wang_hy@jlu.edu.cn E-mail:cui_xj@jlu.edu.cn;wang_hy@jlu.edu.cn
  • 基金资助:

    国家自然科学基金(批准号: 21104023)和教育部博士点新教师基金(批准号: 20090061120078)资助.

Fabrication of Magnetic Protein Microcapsules by Sonochemical Method

WANG Chun-Lei1,2, YAN Jun-Tao1,2, ZHONG Shuang-Ling3, LI Zhan-Feng1, CUI Xue-Jun1, WANG Hong-Yan1   

  1. 1. College of Chemistry, Jilin University, Changchun 130012, China;
    2. Department of Chemistry and Environmental Engineering, Wuhan Polytechnic University, Wuhan 430023, China;
    3. College of Resources and Environment, Jilin Agricultural University, Changchun 130118, China
  • Received:2012-07-06 Online:2013-02-10 Published:2013-01-21

PDF (PC)

被引次数

47

摘要：

通过声化学法制备了具有生物相容性的磁性蛋白质微胶囊, 利用高强度超声波辐照含有油酸改性磁性的Fe3O4纳米粒子的油相与蛋白质水溶液的两相界面, 只需几分钟即可得到磁性蛋白质微胶囊. 这种制备蛋白质微胶囊的方法快速简便, 高效环保, 可将分散于油相的疏水性药物直接装载, 不破坏药物. 在药物靶向传输等领域具有应用性.

关键词: 蛋白质微胶囊, 声化学法, 磁性Fe3O4纳米粒子, 靶向传输

Abstract:

Biocompatible magnetic protein microcapsules(MPMCs) were prepared by sonochemical method. Under high intensity ultrasonic treatment, the MPMCs were yielded at the interface between the oil liquids containing Fe3O4 nanoparticles and the protein solution within several minutes. Meanwhile, the hydrophobic drugs could be loaded into MPMCs directly via sonochemical method and the activities of proteins and drugs were not destroyed. The sonochemical technique is a very simple and cost-effective method to fabricate MPMCs as drug carriers. Such prepared MPMCs are very promising carriers for drug delivery systems and magnetic resonance imaging.

Key words: Protein microcapsule, Sonochemical method, Magnetic Fe3O4 nanoparticle, Targeted delivery

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